Canada has become the second country after Uruguay to legalise possession and use of recreational cannabis.
Medical marijuana has been legal in the country since 2001.
But concerns remain, including about the readiness for police forces to tackle drug impaired driving.
According to BBC News, Information has been sent to 15m households about the new laws and there are public awareness campaigns.
Ian Power, from the town of St John’s began queuing at 20:00 local time so he could “make history”.
Newfoundland is half an hour ahead of the next province to the west.
“It’s been my dream to be the first person to buy the first legal gram of cannabis in Canada, and here I finally am,” he said.
Canadian provinces and municipalities have been preparing for months for the end of cannabis prohibition. They are responsible for setting out where cannabis can be bought and consumed.
This has created a patchwork of more or less restrictive legislation across the country.